Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721)

Table 3 Relationship between time-order and effect in drugs used in combination (^-x±s)

Drugs (mg/L)		Simultaneous exposure	Pre-Cis exposure	Post-Cis exposure
Cis + 5-Fu
2.5	25	0.709 ± 0.015	0.683 ± 0.016	0.598 ± 0.010
5	50	0.859 ± 0.011	0.807 ± 0.027	0.773 ± 0.015
10	100	0.877 ± 0.013	0.824 ± 0.012	0.793 ± 0.026
20	200	0.902 ± 0.014	0.831 ± 0.017	0.805 ± 0.016
40	400	0.951 ± 0.012	0.853 ± 0.015	0.822 ± 0.010
Cis + VCR
2.5	0.25	0.527 ± 0.025	0.470 ± 0.023	0.199 ± 0.023
5	0.5	0.781 ± 0.034	0.707 ± 0.022	0.407 ± 0.017
10	1	0.844 ± 0.015	0.789 ± 0.025	0.533 ± 0.013
20	2	0.873 ± 0.017	0.818 ± 0.029	0.651 ± 0.021
40	4	0.898 ± 0.025	0.893 ± 0.020	0.752 ± 0.025