Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China

Table 2 Changes of p53 and Waf1p21 in esophageal epithelia with different severities of lesions

Histology	p53 immunostaining		Waf1p21 immunostaining
	% of samples with positive stain % (n/N)a	Number of positive cells/mm2 (-x±s)	% of samples with positive stain % (n/N)a	Number of positive cells/mm2 (-x±s)
Normal	74 (23/31)	53 ± 7839	(11/28)	34 ± 72
BCH	87 (102/117)	74 ± 66	38 (14/37)	53 ± 10b
DYS	100 (31/31)	262 ± 341b	27 (3/11)	11 ± 20b
SCC	89 (23/26)	1 297 ± 1110b	14 (1/7)	8 ± 22

^an, positive cases; N, total cases examined.

^bStatistically different from the adjacent low-grade lesion by Wilcoxon rank-sum test, P < 0.01.