Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China

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Aug 15, 1998 (publication date) through Oct 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 15, 1998; 4(4): 287-293
Published online Aug 15, 1998. doi: 10.3748/wjg.v4.i4.287

Table 2 Changes of p53 and Waf1p21 in esophageal epithelia with different severities of lesions

Histology	p53 immunostaining		Waf1p21 immunostaining
Histology	% of samples with positive stain % (n/N)^a	Number of positive cells/mm² (^-x±s)	% of samples with positive stain % (n/N)^a	Number of positive cells/mm² (^-x±s)
Normal	74 (23/31)	53 ± 7839	(11/28)	34 ± 72
BCH	87 (102/117)	74 ± 66	38 (14/37)	53 ± 10^b
DYS	100 (31/31)	262 ± 341^b	27 (3/11)	11 ± 20^b
SCC	89 (23/26)	1 297 ± 1110^b	14 (1/7)	8 ± 22

^an, positive cases; N, total cases examined.

^bStatistically different from the adjacent low-grade lesion by Wilcoxon rank-sum test, P < 0.01.

Citation: Wang LD, Zhou Q, Wei JP, Yang WC, Zhao X, Wang LX, Zou JX, Gao SS, Li YX, Yang C. Apoptosis and its relationship with cell proliferation, p53, Waf1p21, bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China. World J Gastroenterol 1998; 4(4): 287-293
URL: https://www.wjgnet.com/1007-9327/full/v4/i4/287.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.i4.287