Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease

Figure 3 circSOD2 is delivered from hepatocytes to bone marrow mesenchymal stem cells. A: Expression pattern of circSOD2 in various organs and tissues of high-fat diet (HFD) mice (n = 5); B and C: Expression levels of circSOD2 in bone marrow and bone marrow mesenchymal stem cells (BMSCs) of normal diet mice (Con), HFD mice, and HFD mice supplemented with Vitamin C (n = 5); D: Expression levels of circSOD2 in mice BMSCs after cocultured with hepatocytes from Con, HFD, and HFD pretreated with N-acetyl L-cysteine groups (n = 5). ^aP < 0.05; ^bP < 0.01; Con: Control; MDA: Malondialdehyde; HFD: High-fat diet; VitC: Vitamin C; NAC: N-acetyl L-cysteine.