Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

Figure 10  Runchangningshen paste adjusted the relationship between the mucosal microbiota and NLRP6/autophagy pathway to promote mucin-2 secretion in functional constipation rats. A: Heatmap of the correlation between the differential microbiota at the phylum level and NLRP6/autophagy pathway (n = 6); B: Heatmap of the correlation between the differential microbiota at the family level and NLRP6/autophagy pathway (n = 6); C: Heatmap of the correlation between the differential microbiota at the genus level and NLRP6/autophagy pathway (n = 6). The average was used for both clinical factors and species hierarchical clustering methods. We calculated the correlation between variables using the spearman's correlation coefficient. The x-axis and y-axis represent clinical factors and species, respectively. The correlation coefficients (r values) and P values were obtained through calculations. The r values are displayed in the figure using different colors. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.