Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

Figure 8 Runchangningshen paste modulated the mucosal microbiota composition to promote the defecation in functional constipation rats. A: Heatmap of the correlation between the differential microbiota at the phylum level and the indicators of the defecation function (n = 6); B: Heatmap of the correlation between the differential microbiota at the family level and the indicators of the defecation function (n = 6); C: Heatmap of the correlation between the differential microbiota at the genus level and the indicators of the defecation function (n = 6). Average was used for both clinical factors and species hierarchical clustering methods. We calculated the correlation between variables using the Spearman’scorrelation coefficient. The x-axis and y-axis represent clinical factors and species, respectively. The correlation coefficients (r values) and P values were obtained through calculations. The r values are displayed in the figure using different colors. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.