Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study

doi:10.3748/wjg.v31.i9.101383

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Mar 7, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Gastroenterol. Mar 7, 2025; 31(9): 101383
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.101383

Table 1 Basic clinical characteristics of non-alcoholic steatohepatitis patients

Variables	Total (n = 746)	Validation cohort (n = 224)	Training cohort (n = 522)	P value
Age (years)	44.45 ± 15.11	44.03 ± 15.51	44.62 ± 14.95	0.623
Gender				0.328
Female	416 (55.76)	131 (58.48)	285 (54.60)
Male	330 (44.24)	93 (41.52)	237 (45.40)
Hypertension	352 (47.18)	101 (45.09)	251 (48.08)	0.453
Diabetes	345 (46.25)	97 (43.30)	248 (47.51)	0.291
Smoking	137 (18.36)	35 (15.62)	102 (19.54)	0.206
BMI	28.16 ± 4.70	27.82 ± 4.84	28.31 ± 4.63	0.186
ALT	101.39 ± 127.91	90.11 ± 106.34	106.22 ± 135.93	0.115
AST	59.42 ± 77.85	50.85 ± 51.24	63.09 ± 86.59	0.017
Total bilirubin	16.08 ± 18.76	14.76 ± 17.61	16.64 ± 19.22	0.21
Albumin	44.04 ± 4.60	43.86 ± 4.68	44.12 ± 4.57	0.474
γ-GGT	94.74 ± 125.55	85.23 ± 117.60	98.90 ± 128.77	0.183
Creatinine	4.78 ± 1.26	4.77 ± 1.31	4.78 ± 1.25	0.902
Blood urea nitrogen	65.03 ± 14.65	64.49 ± 14.71	65.27 ± 14.64	0.51
Leukocyte	6.35 ± 1.81	6.25 ± 1.78	6.40 ± 1.83	0.317
Platelet	224.33 ± 71.99	227.77 ± 78.80	222.87 ± 68.92	0.422
INR	2.23 ± 9.44	3.22 ± 13.71	1.79 ± 6.77	0.059
Total cholesterol	4.77 ± 0.97	4.78 ± 0.98	4.76 ± 0.96	0.74
Triglyceride	2.23 ± 1.26	2.28 ± 1.33	2.21 ± 1.23	0.477
Complement C3	1.10 ± 0.34	1.09 ± 0.35	1.10 ± 0.33	0.704
Complement C4	0.23 ± 0.08	0.21 ± 0.06	0.23 ± 0.09	0.015
HbA1c	7.28 ± 2.58	7.16 ± 2.52	7.34 ± 2.60	0.504
VCTE-CAP	296.03 ± 46.89	299.15 ± 49.03	294.80 ± 46.04	0.385
VCTE-LSM	9.02 ± 5.05	9.56 ± 6.81	8.81 ± 4.15	0.166
APRI	0.33 ± 0.61	0.29 ± 0.40	0.35 ± 0.69	0.218
FIB-4	241.40 ± 915.28	299.15 ± 49.03	227.76 ± 1017.03	0.437
F3/F4	278 (37.27)	81 (36.16)	197 (37.74)	0.683

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γ-GGT: Gamma-glutamyl transferase; INR: International normalized ratio; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fibrosis index based on the 4 factors; BMI: Body mass index; HbA1c: Glycated hemoglobin; LSM: Liver stiffness measurement.

Citation: Xiong FX, Sun L, Zhang XJ, Chen JL, Zhou Y, Ji XM, Meng PP, Wu T, Wang XB, Hou YX. Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study. World J Gastroenterol 2025; 31(9): 101383
URL: https://www.wjgnet.com/1007-9327/full/v31/i9/101383.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i9.101383