Beyond the tumor region: Peritumoral radiomics enhances prognostic accuracy in locally advanced rectal cancer

Figure 4 Calibration and decision curves of the prognostic models. Calibration curves of integrated clinical-radiological-omics model (Model_ICRO) showing a robust calibration between the predicted 3-year progression-free survival (X-axis) and the actual 3-year progression-free survival (Y-axis). A: In the training; B: Validation sets; Decision curves of model based on the pathological T stage and pathological N stage (grey line), model based on body mass index, pathological N stage, tumor regression grade, and mesorectal fascia status (Model_clin) (yellow line), Model_clin+peri (orange line), and Model_ICRO (blue line) showing the net benefit across a range of threshold probabilities; C: In the training; D: Validation sets. Model_ICRO shows the highest net benefit across most threshold probabilities. ICRO: Integrated clinical-radiological-omics; Clin: Clinicoradiological; PFS: Progression-free survival; Intra: Intratumoral; peri: Peritumoral; ypTN: Pathological T and N stages after neoadjuvant chemoradiotherapy.