Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy: A retrospective cohort study

Table 3 Comparison of postoperative events in relation to postpancreatectomy acute pancreatitis, n (%)

Variables	Without PPAP (n = 293)	PPAP (n = 88)	P value
DFA on POD 1, median (IQR), U/L	553 (82, 2726)	4135 (1379, 8481)	< 0.001
DFA on POD 3, median (IQR), U/L	145 (42, 791)	2349 (627, 6153)	< 0.001
WBC on POD 1, median (IQR), 109/L	12.4 (10.2, 15.0)	13.6 (10.7, 16.9)	0.058
WBC on POD 3, median (IQR), 109/L	9.4 (7.0, 12.5)	11.2 (8.7, 15.1)	< 0.001
CRP on POD 1, median (IQR), mg/L	62.7 (43.2, 90.7)	76.7 (49.8, 116.1)	0.005
CRP on POD 3, median (IQR), mg/L	101.3 (67.0, 142.3)	153.3 (81.0, 201.1)	< 0.001
Serum AMY on POD 1, median (IQR), U/L	110.5 (53.0, 249.3)	312.0 (189.4, 508.3)	< 0.001
Serum AMY on POD 3, median (IQR), U/L	30.0 (18.2, 59.0)	95.0 (62.6, 149.0)	< 0.001
Drain removal time, median (IQR), days	12 (9, 20)	25 (14, 33)	< 0.001
Postoperative hospital stay, median (IQR), days	15.0 (11, 21)	23.5 (15, 33)	< 0.001
POPF	43 (14.7)	49 (55.7)	< 0.001
Grade C POPF	4 (1.4)	8 (9.1)	0.001
DGE	78 (26.6)	34 (38.6)	0.042
PPH	21(7.2)	18 (20.5)	0.001
Interventional treatment	26 (8.9)	28 (31.8)	< 0.001
Biliary fistula	7 (2.4)	5 (5.7)	0.229
Re-operation	8 (2.7)	11 (12.5)	0.001
Organ failure	1 (0.3)	6 (6.8)	< 0.001
90-day mortality	7 (2.4)	7 (8.0)	0.035
30-day readmission	9 (3.1)	6 (6.8)	0.203

PPAP: Postpancreatectomy acute pancreatitis; DFA: Drain fluid amylase; POD: Postoperative day; IQR: Interquartile range; WBC: White blood cell count; CRP: C-reactive protein; AMY: Amylase; POPF: Postoperative pancreatic fistula; DGE: Delayed gastric emptying; PPH: Postpancreatectomy hemorrhage.