Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression

Figure 8 Expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B mRNA in the hippocampus. A: Expression of brain-derived neurotrophic factor mRNA in depression groups; B: Expression of brain-derived neurotrophic factor mRNA in chronic restraint stress, dextran sodium sulfate and compound model groups; C: Expression of tropomyosin receptor kinase B mRNA in depression groups; D: Expression of tropomyosin receptor kinase B mRNA in chronic restraint stress, dextran sodium sulfate and compound model groups. ^aP < 0.01 vs control group; ^bP < 0.01 vs chronic restraint stress group; ^cP < 0.01 vs chronic restraint stress + dextran sodium sulfate group. CUMS: Chronic restraint stress; DSS: Dextran sodium sulfate; LD: Low-dose Wuling powder; MD: Medium-dose Wuling powder; HD: High-dose Wuling powder; FLU: Fluoxetine; MS: Mesalazine; BDNF: Brain-derived neurotrophic factor; TrkB: Tropomyosin receptor kinase B.