Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression

doi:10.3748/wjg.v31.i8.100227

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Feb 28, 2025 (publication date) through Feb 22, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2025; 31(8): 100227
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.100227

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Figure 1 Flowchart of intervention and outcome evaluation. A: Molding flow chart; B: Group administration and index detection. CUMS: Chronic restraint stress; DSS: Dextran sodium sulfate; NS: Normal saline; LD: Low-dose Wuling powder; MD: Medium-dose Wuling powder; HD: High-dose Wuling powder; FLU: Fluoxetine; MS: Mesalazine; PCR: Polymerase chain reaction; proBDNF: Brain-derived neurotrophic factor precursor; p75NTR: P75 neurotrophin receptor; TrkB: Tropomyosin receptor kinase B; TNF: Tumor necrosis factor; IL: Interleukin.

Citation: Wang JJ, Fan YH, Cao WT, Huang R, Yao XY, Li ML. Mechanism of Wuling powder modulating proBDNF/p75NTR/sortilin and BDNF/TrkB pathways in the treatment of ulcerative colitis complicated with depression. World J Gastroenterol 2025; 31(8): 100227
URL: https://www.wjgnet.com/1007-9327/full/v31/i8/100227.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i8.100227