Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43

Figure 2 Glial cell line-derived neurotrophic factor protects against colonic histopathological damage and reduces inflammation in dextran sodium sulfate-induced ulcerative colitis mice. A: Representative colon tissue sections stained by hematoxylin and eosin staining showing histopathological changes in each group (scale bar: 100 μm); B: Histological scores; Quantification of serum levels of C: C-reactive protein; D: Tumor necrosis factor-α; E: Interleukin-1β; F: Interleukin-6 using enzyme-linked immunosorbent assay. Data were presented as mean ± SD (n = 8). ^aP < 0.05. ^bP < 0.01. GDNF: Glial cell line-derived neurotrophic factor; UC: Ulcerative colitis; CN: Normal control; CRP: C-reactive protein; TNF-α: Tumor necrosis factor-α; IL: Interleukin.