Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway

Figure 3 Regulation of protein and gene expression related to signal transducer and activator of transcription 3/nuclear factor kappa B signaling pathway in colonic tissue by mesalazine. A: P-signal transducer and activator of transcription 3 protein level; B: Nuclear factor kappa B protein level; C: p-IκB protein level; D: Signal transducer and activator of transcription 3 and nuclear factor kappa B gene levels. Compared with the IL-10^-/- group, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. STAT3: Signal transducer and activator of transcription 3; WT: Wild type; IL: Interleukin; ASA: Amino salicylic acid; NF-κB: Nuclear factor kappa B.