Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway

Figure 2 Effect of mesalazine on alleviating endoplasmic reticulum stress in interleukin-10^-/- mouse colonic epithelial cells. A: Transmission electron microscope photograph of mouse colonic epithelial cells (magnification × 8200); B: Glucose-regulated protein 78 protein level; C: Representative images of glucose-regulated protein 78 immunofluorescence (green) and nuclei (blue) in colonic tissue; D: Representative images of C/EBP homologous protein immunofluorescence (green) and nuclei (blue) in colonic tissue. Compared with the interleukin-10^-/- group, ^aP < 0.05, ^bP < 0.01. WT: Wild type; IL: Interleukin; ASA: Amino salicylic acid; GRP78: Glucose-regulated protein 78; DAPI: 4’,6-diamidino-2-phenylindole; CHOP: C/EBP homologous protein.