Persistent challenges in the diagnosis of acute pancreatitis due to primary hyperparathyroidism during pregnancy

Figure 2 Mechanisms of acute pancreatitis due to hyperparathyroidism during pregnancy. This figure outlines the two principal mechanisms contributing to acute pancreatitis: Increased trypsinogen activation due to elevated calcium levels and increased calcium deposition. This finding also highlights the exacerbating role of genetic variants, with serine peptidase inhibitor Kazal type 1 mutations intensifying trypsinogen activation and cystic fibrosis transmembrane conductance regulator mutations promoting calcium deposition. SPINK1: Serine peptidase inhibitor Kazal type 1; CFTR: Cystic fibrosis transmembrane conductance regulator.