Differences in diversity and composition of mucosa-associated colonic microbiota in colorectal cancer and non-colorectal cancer in Indonesia

Table 6 Comparison of microbiota diagnostic values

Parameters	Fusobacterium nucleatum	Bacteroides fragilis	Combination of Fusobacterium nucleatum and Bacteroides fragilis
AUC (95%CI)	0.727 (0.600-0.853)	0.735 (0.607-0.862)	0.786 (0.671-0.900)
P value	0.003	0.002	< 0.001b
Cut-off value	≥ 0.0117	≥ 0.0836	Fusobacterium nucleatum ≥ 0.0117; Bacteroides fragilis ≥ 0.0836
Sensitivity	65.7 (47.8-80.9)	68.6 (50.7-83.2)	82.8 (66.4-93.4)
Specificity	62.5 (40.6-81.9)	66.7 (44.7-84.4)	50 (29.1-70.9)
Positive likelihood ratio	1.75	2.06	1.66
Negative likelihood ratio	0.55	0.47	0.34
Positive predictive value	71.9 (59.1-81.9)	75.0 (62.1-84.7)	70.7 (61.2-78.8)
Negative predictive value	55.6 (41.8-68.5)	59.3 (45.3-71.9)	66.7 (46.6-82.1)
Accuracy	64.4 (50.9-76.5)	67.8 (54.4-79.4)	69.5 (56.1-80.8)

^bP < 0.001.

AUC: Area under the curve; CI: Confidence interval.