Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway

Figure 7 Effects of mixed lineage kinase domain-like protein adenosine triphosphate pocket inhibitor on alcoholic liver disease model after lipopolysaccharide stimuli in liver organoid system. Liver organoids were treated with lipopolysaccharide to create an alcohol-induced liver disease model. After mixed lineage kinase domain-like protein adenosine triphosphate pocket-binding inhibitor treatment after necroptotic stimuli, the expression of tumor necrosis factor-α, CXCL1/CXCL2, ICAM, and VCAM decreased in the organoid system. ^cP < 0.001. ^dP < 0.0001. TNF: Tumor necrosis factor; DMSO: Dimethyl sulfoxide; LPS: Lipopolysaccharide; CPD: Compound.