Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable?

Figure 4 Impact of sampling protocol on the detection rate of microvascular invasion. A: Sequential comparisons of microvascular invasion detection rates were made for protocols A-E. Statistical analysis was conducted via paired χ² tests to compare protocol A vs B, B vs C, and C vs D, whereas the χ² test was used for comparing protocol D vs E; B: The optimal number of whole-mount slide images was further determined by comparing protocols B and C. Paired χ² tests were used for all comparisons, where whole-mount slide imaging WSI₁-WSI₄ correspond to the number of WSIs (1-4), respectively. MVI: Microvascular invasion; WSI: Whole-mount slide imaging.