Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable?

Table 4 Comparisons of the number of microvascular invasion in metastatic distance groups using various sampling protocols, n (%)

MVI metastatic distance groups	Sampling protocol
	A	P value1	B	P value2	C	P value3	D	P value4	E
≤ 1.0 mm	12 (80.0)	0.004	22 (61.1)	< 0.001	64 (59.8)	1.000	64 (51.2)	0.005	118 (29.9)
1.1-3.0 mm	2 (13.3)	0.066	9 (25.0)	0.014	20 (18.7)	0.083	23 (18.4)	0.005	86 (21.8)
3.1-5.0 mm	0 (0.0)	0.083	3 (8.3)	0.041	12 (11.2)	0.102	16 (12.8)	0.006	45 (11.4)
5.1-10.0 mm	1 (6.7)	0.317	2 (5.6)	0.039	10 (9.4)	0.102	14 (11.2)	0.014	74 (18.7)
> 10.0 mm	0 (0.0)	1.000	0 (0.0)	0.317	1 (0.9)	0.066	8 (6.4)	0.008	72 (18.2)

¹The Wilcoxon matched-pairs signed-rank sum test was used to compare A vs B.

²The Wilcoxon matched-pairs signed-rank sum test was used to B vs C.

³The Wilcoxon matched-pairs signed-rank sum test was used to C vs D.

⁴The Mann-Whitney U test was used to compare D vs E.

MVI: Microvascular invasion.