Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable?

Table 3 Performance of protocols A, B, C, D, and three consecutive interval whole-mount slide images at the tumor center for detecting microvascular invasion in 15 specimens, using protocol E as the reference standard

Metrics	Protocol A	Protocol B	WSI3/protocol C/protocol D
Positive rate	0.40 (6/15)	0.53 (8/15)	0.60 (9/15)
Accuracy	0.47 (0.22-0.73)	0.60 (0.33-0.83)	0.67 (0.39-0.87)
Sensitivity	0.43 (0.19-0.70)	0.57 (0.30-0.81)	0.64 (0.36-0.86)
Specificity	1.00 (0.05-1.00)	1.00 (0.05-1.00)	1.00 (0.05-1.00)
Positive predictive value	1.00 (0.52-1.00)	1.00 (0.60-1.00)	1.00 (0.63-1.00)
Negative predictive value	0.11 (0.01-0.49)	0.14 (0.01-0.58)	0.17 (0.01-0.64)
False negative rate	0.57 (0.30-0.81)	0.43 (0.19-0.70)	0.36 (0.14-0.64)

WSI₃: Three consecutive interval whole-mount slide images at the tumor center.