Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma: Is it reliable?

Table 2 Performance of protocols A, B, C, D, and three consecutive interval whole-mount slide images at the tumor center for detecting microvascular invasion in 37 specimens, using the overall microvascular invasion detection rate as the reference standard

Metrics	Protocol A	Protocol B	WSI3	Protocol C	Protocol D
Positive rate	0.27 (10/37)	0.43 (16/37)	0.59 (22/37)	0.62 (23/37)	0.68 (25/37)
Accuracy	0.46 (0.42-0.75)	0.62 (0.45-0.77)	0.78 (0.61-0.90)	0.81 (0.64-0.91)	0.86 (0.70-0.95)
Sensitivity	0.33 (0.18-0.53)	0.53 (0.35-0.71)	0.73 (0.54-0.87)	0.77 (0.57-0.89)	0.83 (0.65-0.94)
Specificity	1.00 (0.56-1.00)	1.00 (0.56-1.00)	1.00 (0.56-1.00)	1.00 (0.56-1.00)	1.00 (0.56-1.00)
Positive predictive value	1.00 (0.66-1.00)	1.00 (0.76-1.00)	1.00 (0.82-1.00)	1.00 (0.82-1.00)	1.00 (0.83-1.00)
Negative predictive value	0.26 (0.12-0.47)	0.33 (0.15-0.57)	0.47 (0.22-0.73)	0.50 (0.24-0.76)	0.58 (0.29-0.84)
False negative rate	0.67 (0.47-0.82)	0.47 (0.29-0.65)	0.27 (0.13-0.46)	0.23 (0.11-0.43)	0.17 (0.06-0.35)

WSI₃: Three consecutive interval whole-mount slide images at the tumor center.