Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease

Table 3 Multivariable regression analysis for disease-free survival, overall survival and cancer-specific survival

	DFS		OS		CSS
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
LVI		0.001		< 0.001		0.003
No	1		1		1
Yes	3.368 (1.628-6.966)		5.972 (2.184-16.33)		4.933 (1.736-14.02)
PNI		0.002		0.007		0.011
No	1		1		1
Yes	3.055 (1.478-6.313)		5.643 (1.615-19.72)		5.170 (1.459-18.32)
pT stage		0.009		0.239		0.252
2 and 3	1		1		1
4	3.523 (1.378-9.009)		2.621 (0.526-13.05)		2.561 (0.513-12.80)
NLN (n)		0.171		0.333		0.233
≥ 12	1		1		1
< 12	1.698 (0.796-3.623)		1.668 (0.592-4.698)		1.904 (0.661-5.482)

DFS: Disease-free survival; OS: Overall survival; CSS: Cancer-specific survival; HR: Hazard ratio; CI: Confidence interval; LVI: Lymphovascular invasion; PNI: Perineural invasion; NLN: Negative lymph nodes.