Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease

Table 2 Univariable regression analysis for disease-free survival, overall survival and cancer-specific survival

	DFS		OS		CSS
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
LVI		< 0.001		< 0.001		< 0.001
No	1		1		1
Yes	3.510 (1.785-6.902)		7.373 (2.947-18.45)		6.040 (2.314-15.77)
PNI		< 0.001		< 0.001		0.002
No	1		1		1
Yes	3.753 (1.830-7.700)		8.259 (2.393-28.50)		7.320 (2.090-25.64)
Age (years)		0.506		0.393		0.459
≤ 50	1		1		1
> 50	1.494 (0.458-4.873)		2.407 (0.321-18.03)		2.144 (0.284-16.17)
Sex		0.320		0.627		0.330
Female	1		1		1
Male	1.397 (0.723-2.696)		1.251 (0.508-3.081)		1.617 (0.615-4.253)
cT stage		0.414		0.392		0.392
2	1		1		1
3	1.360 (0.469-3.949)	0.572	1.231 (0.270-5.627)	0.788	1.231 (0.270-5.627)	0.788
4	1.539 (0.511-4.634)	4.634	2.224 (0.663-7.466)	0.196	2.224 (0.663-7.466)	0.196
cN stage		0.869		0.733		0.733
0	1		1		1
1	2.446 (0.826-7.238)	0.106	1.998 (0.423-9.438)	0.382	1.998 (0.423-9.438)	0.382
2	1.067 (0.553-2.060)	0.847	1.180 (0.482-2.887)	0.717	1.180 (0.482-2.887)	0.717
Poorly differentiated		0.280		0.204		0.550
No	1		1		1
Yes	1.687 (0.653-4.357)		2.228 (0.647-7.678)		1.570 (0.358-6.896)
pT stage		0.035		0.599		0.490
2 and 3	1		1		1
4	2.580 (1.070-6.220)		1.482 (0.342-6.421)		1.682 (0.384-7.364)
Mucinous adenocarcinoma		0.209		0.224		0.267
No	1		1		1
Yes	0.468 (0.143-1.529)		0.286 (0.038-2.149)		0.318 (0.042-2.406)
TD (n)		0.168		0.365		0.470
= 1	1		1		1
> 1	1.603 (0.820-3.134)		1.540 (0.605-3.919)		1.444 (0.533-3.914)
NLN (n)		0.063		0.194		0.116
> 12	1		1		1
≤ 12	2.045 (0.961-4.351)		1.969 (0.709-5.469)		2.308 (0.813-6.554)

DFS: Disease-free survival; OS: Overall survival; CSS: Cancer-specific survival; HR: Hazard ratio; CI: Confidence interval; LVI: Lymphovascular invasion; PNI: Perineural invasion; TD: Tumor deposit; NLN: Negative lymph nodes.