Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease

Table 1 Comparison of clinicopathologic characteristics based on lymphovascular invasion and perineural invasion

	LVI (no)	LVI (yes)	χ2	P value	PNI (no)	PNI (yes)	χ2	P value
PNI			4.909	0.027
No	51	8
Yes	33	15
Age (years)			3.259	0.071			0.144	0.704
≤ 50	7	5			6	6
> 50	77	18			53	42
Sex			0.150	0.699			1.081	0.299
Female	44	11			33	22
Male	40	12			26	26
cT stage			1.952	0.377			0.068	0.967
2	10	5			8	7
3	51	13			36	28
4	1	1			1	1
cN stage			0.209	0.901			9.349	0.009
0	14	5			9	10
1	33	9			19	23
2	15	5			17	3
Poorly differentiated			1.606	0.205			0.358	0.550
No	77	19			52	44
Yes	7	4			7	4
pT stage			0.864	0.353			0.105	0.746
2 and 3	75	22			53	44
4	9	1			6	4
Mucinous adenocarcinoma			0.276	0.599			0.937	0.333
No	73	19			49	43
Yes	11	4			10	5
TD (n)			0.122	0.727			1.844	0.175
= 1	58	15			37	36
> 1	26	8			22	12
NLN (n)			0.506	0.477			0.231	0.631
> 12	71	18			50	39
≤ 12	13	5			9	9

LVI: Lymphovascular invasion; PNI: Perineural invasion; TD: Tumor deposit; NLN: Negative lymph nodes.