Imaging characteristics of brain microstructure and cerebral perfusion in Crohn’s disease patients with anxiety: A prospective comparative study

Table 5 Brain regions with significant differences in diffusion kurtosis imaging parameters between the Crohn’s disease and healthy control groups

Indexes	Brain regions	AAL	MNI coordinates			P value
			X	Y	Z
AK	Right insula	30	46	2	-4	0.019a
	Left superior temporal	82	64	20	12	0.002a
	Right thalamus	78	0	2	22	0.001a
	Right insula	30	32	0	-8	0.023a
	Left superior temporal	82	56	0	-2	0.015b
	Right thalamus	78	8	28	0	0.031b
	Left medial temporal	85	56	4	-26	0.006b
	Right inferior temporal	90	44	10	44	0.001b
	Left lingual gyrus	47	28	80	-16	0.007b
	Right insula	30	42	0	8	0.002c
	Right anterior cuneate lobe	68	8	52	6	0.017c
RK	Right cerebellar region 6	100	4	32	40	0.021a
	Right cerebellar region 6	100	4	0	4	0.012b
	Left hippocampus	37	14	6	-14	0.004b

^aP < 0.05 for the Crohn’s disease (CD) without anxiety group vs the healthy control group.

^bP < 0.05 for the CD with anxiety group vs the healthy control group.

^cP < 0.05 for the CD with anxiety group vs the CD without anxiety group.

CD: Crohn’s disease; AAL: Automatic anatomical marking; MNI: Montreal Neurological Institute; AK: Axial diffusion kurtosis; RK: Radial diffusion kurtosis.