Imaging characteristics of brain microstructure and cerebral perfusion in Crohn’s disease patients with anxiety: A prospective comparative study

Table 2 Slow apparent diffusion coefficient values in the participants

Brain ROI	ADCslow value (10-3 mm2/second)			P value1
	CD with anxiety (n = 16)	CD without anxiety (n = 21)	Healthy controls (n = 20)
Left frontal lobe	0.876 ± 0.071	0.871 ± 0.028	0.820 ± 0.014	< 0.001a
Left parietal lobe	0.819 ± 0.084	0.827 ± 0.010	0.753 ± 0.065	0.128
Left temporal lobe	0.703 ± 0.038	0.716 ± 0.034	0.648 ± 0.028	< 0.001a
Left occipital lobe	0.656 ± 0.044	0.711 ± 0.026	0.645 ± 0.069	0.052
Left insular lobe	0.743 ± 0.050	0.682 ± 0.025	0.656 ± 0.029	< 0.001a
Right frontal lobe	0.872 ± 0.068	0.852 ± 0.017	0.821 ± 0.028	0.001a
Right parietal lobe	0.818 ± 0.084	0.828 ± 0.011	0.754 ± 0.058	0.142
Right temporal lobe	0.664 ± 0.038	0.671 ± 0.023	0.629 ± 0.044	0.001a
Right occipital lobe	0.684 ± 0.054	0.694 ± 0.047	0.676 ± 0.059	0.193
Right insular lobe	0.758 ± 0.061	0.687 ± 0.024	0.658 ± 0.056	< 0.001a

¹One-way analysis of variance.

^aP < 0.05.

ADC_slow: Slow apparent diffusion coefficient; ROI: Region of interest; CD: Crohn’s disease.