Nomogram based on a novel nutritional immune-inflammatory status score to predict postoperative outcomes in esophageal squamous cell carcinoma

Table 2 Results of univariate and multivariate Cox regression analysis for overall survival in the training set

Variables	Univariate Cox regression analysis for OS		Multivariate Cox regression analysis for OS
	HR	P value	HR	P value
NIIS score, ≥ -6.58 vs < -6.58	2.497 (1.802, 3.458)	< 0.001	2.232 (1.599, 3.117)	< 0.001
Age	1.085 (1.058, 1.112)	< 0.001	1.073 (1.046, 1.101)	< 0.001
Size	1.264 (1.153, 1.385)	< 0.001	1.194 (1.082, 1.319)	< 0.001
Gender, female vs male	1.170 (0.805, 1.700)	0.412
Type of surgery
Sweet esophagectomy	1
Ivor-Lewis esophagectomy	1.079 (0.556, 2.097)	0.821
Thoracoscopic esophagectomy	1.413 (0.747, 2.672)	0.288
McKeown esophagectomy	0.886 (0.638, 1.232)	0.473
Site
Upper	1
Middle	2.735 (0.859, 8.714)	0.089
Lower	2.893 (0.917, 9.127)	0.07
Grade
G1	1
G2	1.457 (0.831, 2.554)	0.189	1.231 (0.697, 2.176)	0.474
G3	3.594 (1.998, 6.465)	< 0.001	2.124 (1.158, 3.899)	0.015
pT
T1	1
T2	0.960 (0.611, 1.507)	0.859
T3	1.338 (0.897, 1.998)	0.154
T4	1.267 (0.816, 1.967)	0.291
pN
N0	1
N1	1.579 (1.073, 2.324)	0.02	1.581 (0.890, 2.810)	0.118
N2	3.432 (2.306, 5.109)	< 0.001	2.950 (1.517, 5.740)	0.001
N3	6.749 (3.481, 13.084)	< 0.001	6.426 (2.312, 17.864)	< 0.001
TNM
I	1
II	1.290 (0.812, 2.049)	0.281	1.003 (0.626, 1.609)	0.989
III	1.941 (1.288, 2.924)	0.002	0.899 (0.481, 1.680)	0.738
IV	4.099 (2.377, 7.069)	< 0.001	0.842 (0.335, 2.115)	0.714
Venous invasion, No vs Yes	1.390 (0.908, 2.129)	0.129
Perineural invasion, No vs Yes	1.080 (0.683, 1.708)	0.742
Pathological type
Superficial type	1
Medullary type	1.072 (0.746, 1.541)	0.705
Fungating type	1.102 (0.399, 3.046)	0.851
Ulcerative type	0.879 (0.581, 1.329)	0.541
Infiltrating type	1.455 (0.354, 5.970)	0.603
Surgical margin, R0 vs R1-2	1.257 (0.516, 3.062)	0.614

OS: Overall survival; NIIS: Nutritional immune-inflammatory status.