Impact of microplastics on the human digestive system: From basic to clinical

doi:10.3748/wjg.v31.i4.100470

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Jan 28, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2025; 31(4): 100470
Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.100470

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Figure 3 Mechanism of how microplastics influence lipid metabolism in liver. Microplastics up-regulate the expression of cytochrome P4502E1 and promote lipid peroxidation; down-regulate the expression of peroxisome proliferator-activated receptor and affect lipid metabolism; induce mitochondrial autophagy through the adenosine5’-monophosphate-activated protein kinase/UNC-51-like kinase pathway and affect energy supply; and carry fatty acids into the liver. MPs: Microplastics; CYP2E1: Cytochrome P4502E1; PPAR: Peroxisome proliferator-activated receptor; LPO: Lipid peroxides; AMPK: Adenosine5’-monophosphate-activated protein kinase; ULK1: UNC-51-like kinase; FA: Fatty acid; ATP: Adenosine triphosphate.

Citation: Wang YF, Wang XY, Chen BJ, Yang YP, Li H, Wang F. Impact of microplastics on the human digestive system: From basic to clinical. World J Gastroenterol 2025; 31(4): 100470
URL: https://www.wjgnet.com/1007-9327/full/v31/i4/100470.htm
DOI: https://dx.doi.org/10.3748/wjg.v31.i4.100470