C-X-C chemokine receptor type 5+CD8+ T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferon-alpha treatment

Figure 3 Comparison of immune markers and interleukin-21 concentration between healthy controls and chronic hepatitis B patients at baseline. A: Frequency of programmed death-ligand 1 (PD-L1)⁺ cells; B: Frequency of C-X-C chemokine receptor type 5 (CXCR5)⁺ cells; C: Frequency of PD-L1⁺CD8⁺ T cells; D: Frequency of CXCR5⁺CD8⁺ T cells; E: Interleukin-21 concentration; F: Frequency of PD-L1⁺CD4⁺ T cells; G: Frequency of CXCR5⁺CD4⁺ T cells. CXCR5: C-X-C chemokine receptor type 5; PD-L1: Programmed death-ligand 1; IL-21: Interleukin-21.