C-X-C chemokine receptor type 5+CD8+ T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferon-alpha treatment

Table 2 Logistic regression analyses for sustained Hepatitis Be antigen seroconversion at week 12

Characteristics	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	OR	95%CI	P value
ALT	1.002	0.998-1.002	0.383	1.008	0.999-1.014	0.063
IL-21	0.999	0.994-1.004	0.645
PDL1	0.957	0.891-1.029	0.236
CXCR5	1.038	0.953-1.131	0.395	0.652	0.387-1.098	0.107
PDL1+CD8+	1.070	0.959-1.193	0.225
PDL1+CD4+ (%)	0.85	0.733-0.984	0.018a
CXCR5+CD8+	1.459	1.125-1.892	0.004b	4.820	1.081-21.487	0.039a
CXCR5+CD4+	0.952	0.853-1.062	0.375
log10 HBV DNA	0.412	0.241-0.705	0.001b
log10 HBsAg	0.126	0.032-0.507	0.004b
log10 HBeAg	0.300	0.144-0.626	0.001b	0.009	0.001-0.490	0.021a

^aP < 0.05.

^bP < 0.01.

ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBeAg: Hepatitis Be antigen; IL-21: Interleukin-21; CXCR5: C-X-C chemokine receptor type 5; PD-L1: Programmed death-ligand 1.