Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

Table 2 Event summary of Joint Modeling of Longitudinal and Survival data and hazard ratios

Variable	JMLS1 (total)		JMLS2 (males)		JMLS3 (females)
	HR	P value	HR	P value	HR	P value
Ratio	1.069 (0.923–1.216)	> 0.05	1.034 (0.882–1.213)	> 0.05	1.149 (0.865–1.526)	> 0.05
Cage	1.069 (1.057–1.081)	< 0.01	1.068 (1.055, 1.082)	< 0.01	1.071 (1.045–1.098)	< 0.01
Gender	0.480 (0.377–0.610)	< 0.01	-	-	-	-
Liver cirrhosis	4.570 (3.376–6.185)	< 0.01	4.896 (3.428, 6.994)	< 0.01	3.690 (2.075–6.561)	< 0.01
α	2.065 (1.749-2.439)	< 0.01	2.005 (1.653–2.431)	< 0.01	2.273 (1.620–3.190)	< 0.01

JMLS₁: Joint Modeling of Longitudinal and Survival data for the overall population; JMLS₂: Joint Modeling of Longitudinal and Survival data for males; JMLS₃: Joint Modeling of Longitudinal and Survival data for females; Ratio: Ln(10 alkaline phosphatase to prealbumin ratio); Cage: Baseline age after centralization; Liver cirrhosis: Whether cirrhosis had occurred at baseline; α: The joint coefficient of the joint model.