Imaging characteristics of hypervascular focal nodular hyperplasia-like lesions in patients with chronic alcoholic liver disease

Figure 4 Histopathological and Immunohistochemical features of the non-nodular and nodular portions (A, C: Non-nodular, B, D, E: Nodular). A and B: Cell density, iron deposits, and sinusoidal capillarization in the surrounding liver tissue and the focal nodular hyperplasia (FNH)-like nodule. The FNH-like nodule shows increased cell density (A: hematoxylin and eosin staining × 400); C and D: OATP8 (red-orange color) is expressed on the cellular membrane of hepatocytes at the sinusoidal side. The expression of OATP8 is nearly absent in the nodule (B: × 400); however, it is diffusely found in the surrounding tissue (C: × 400). OATP8 is immunohistochemically detected using anti-OATP8; E: Immunohistochemical staining of CD68 antigen showing Kupffer cells. The staining of nodule CD68 antigen shows diffuse Kupffer cell infiltration.