RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

Figure 4 The expression level of regulator of G protein signaling 4 affected the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial mesenchymal transition in gastric cancer cells. A: Gene Set Enrichment Analysis results showed the relevant pathways that regulator of G protein signaling 4 may affected in The Cancer Genome Atlas Stomach Cancer dataset; B-E: The expression levels of focal adhesion kinase signaling pathway and epithelial mesenchymal transition related protein of MGC-803 cells and AGS cells were determined by western blot analysis. β-actin was used as a loading control. ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. FAK: Focal adhesion kinase; PI3K: Phosphatidyl-inositol-3-kinase; AKT: Protein kinase B.