RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

Figure 1 High expression of regulator of G protein signaling 4 was associated with poor prognosis in patients with gastric cancer. A: Differential expression of regulator of G protein signaling 4 (RGS4) in The Cancer Genome Atlas Stomach Cancer dataset (TCGA-STAD); B: Differential expression of RGS4 in the integrated analysis of TCGA-STAD and the Genotype-Tissue Expression dataset; C: High expression of RGS4 was associated with lower overall survival in TCGA-STAD dataset; D: The correlation between RGS4 and T stage, N stage, M stage, tumor-node-metastasis stage and tumor grade of gastric cancer (GC); E: Differential expression of RGS4 in GC and para-carcinoma normal tissues of our center’s patients; F: Representative immunohistochemistry images showing the expression of RGS4 in GC and para-carcinoma normal tissues (strong staining: +++; moderate staining: ++; weak staining: +; negative staining: -); G: Differences in protein expression levels of RGS4 between GC and para-carcinoma normal tissues; H: High expression of RGS4 was associated with lower overall survival in GC patients in our center. ^bP < 0.01, ^cP < 0.001. RGS4: Regulator of G protein signaling 4; GC: Gastric cancer.