Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation

Figure 6 Bicuculline mitigated liver damage and steatosis in WT mice that were fed a methionine/choline-deficient diet. A: Experimental diagram of feeding metabolic dysfunction-associated steatotic liver disease model mice that were fed a methionine/choline-deficient diet; B: Representative macroscopic image of mouse liver, representative images of oil red O staining, and representative images of hematoxylin & eosin staining (200 ×); C: Changes in mouse body weight; D: Mouse liver indices; E and F: Serum total triglyceride and cholesterol contents; G and H: Absolute values of alanine aminotransferase and aspartate aminotransferase enzyme activities in the serum; I and J: Relative total triglyceride and cholesterol contents in liver tissues. The results are expressed as the means ± SD (n = 5). Compared with the model group. ^aP < 0.05; ^bP < 0.01; H&E: Hematoxylin & eosin; BIC: Bicuculline.