Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation

Figure 4 Bicuculline may regulate lipid metabolism disorders in metabolic dysfunction-associated steatotic liver disease through the inflammatory response and metabolic reprogramming. A and B: Volcano plot of differentially expressed genes in the control vs model and model vs bicuculline (BIC) groups; C: Venn diagram; D and E: Differential gene heatmap of the control vs model and model vs BIC groups; F: Gene Ontology enrichment analysis; G: Kyoto Encyclopedia of Genes and Genomes signaling pathway analysis. KEGG: Kyoto Encyclopedia of Genes and Genomes.