Bicuculline ameliorates metabolic dysfunction-associated steatotic liver disease by inhibiting the nuclear factor-kappa B pathway and reducing lipid accumulation

Figure 1 Developmental toxicity of bicuculline in zebrafish embryos. A: Chemical structure of bicuculline (BIC) derived from PubChem; B: Survival rate of zebrafish embryos exposed to 0-400 μM BIC for timepoints ranging from 24 to 96 hours; C: Hatching rate of zebrafish embryos exposed to from 0 to 400 μM BIC for 96 hours; D: Body length of zebrafish embryos exposed to 0-400 μM BIC for 96 hours; E: Heart rate of zebrafish embryos exposed to 0-400 μM BIC for 96 hours; F: Phenotypic changes in zebrafish embryos exposed to 0-400 μM BIC for 24, 48, 72, and 96 hours. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.