Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor

Figure 6 DL-tryptophan water inhibits necroptosis to mitigate sepsis-induced intestinal injury via aryl hydrocarbon receptor. A and B: Western blotting of aryl hydrocarbon receptor; C-F: Western blotting of phospho-receptor-interacting protein kinase (p-RIPK) 1, receptor-interacting protein kinase (RIPK) 1; G-J: Western blotting of pRIPK3, RIPK3; K-N: Western blotting of phospho-mixed lineage kinase domain-like protein, mixed lineage kinase domain-like protein; O-R: Western blotting of pro-caspase-3, and cleaved caspse-3 normalized to glyceraldehyde-3-phosphate dehydrogenase. ^aP < 0.05. ^bP < 0.01. CLP: Cecal ligation and puncture; DL-Trp: DL-tryptophan; AhR: Aryl hydrocarbon receptor; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; p-RIPK: Phospho-receptor-interacting protein kinase; RIPK: Receptor-interacting protein kinase; MLKL: Mixed lineage kinase domain-like protein; p-MLKL: Phospho-mixed lineage kinase domain-like protein.