Ozone controls the metabolism of tryptophan protecting against sepsis-induced intestinal damage by activating aryl hydrocarbon receptor

Figure 1 Ozone-rich water mitigates sepsis-induced intestinal injury diagram of the mouse model. A: Diagram of the mouse model; B: Survival of mice shown by Kaplan-Meier curves; C and D: Hematoxylin-eosin staining and histopathological score; E and F: Zonula occludens-1 (ZO-1) and occludin levels shown by immunofluorescent staining; G-J: Western blotting of occludin and ZO-1 normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH); K and L: Immunohistochemistry of interleukin-6 and tumor necrosis factor-α in the colon; M: F4/80 levels shown by immunofluorescence staining; N and O: Immunofluorescence staining of cluster of differentiation (CD) 86 and CD206; P-S: Western blotting of CD206 and CD86, normalized to GAPDH. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. CLP: Cecal ligation and puncture; IL-6: Interleukin-6; CD: Cluster of differentiation; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase; TNF-α: Tumor necrosis factor-α; ZO-1: Zonula occludens-1.