Protein-losing enteropathy and multiple vasculature dysplasia in LZTR1-related Noonan syndrome: A case report and review of literature

Figure 2 Imaging presentation about the liver and gastrointestinal tract. A and B: Abdominal enhanced computed tomography by three-dimensional reconstruction indicating cavernous transformation of portal vein; C-F: Liver histology suggesting porto-sinusoidal vascular disease. The discernable lobular architecture (C: Hematoxylin and eosin staining, 200 ×), stenosis or disappearance of portal veins in portal areas (D: Reticular staining, 400 ×), herniated portal veins into the liver parenchyma, and smooth muscle proliferation in portal areas (E: Masson-trichrome staining, 200 ×), inflammatory cell infiltration not obvious in the portal areas (F: Hematoxylin and eosin staining, 400 ×); G and H: Upper and lower endoscopies showed no obvious abnormalities in the gastric and duodenal mucosa; I and J: No obvious abnormalities in the ileal and colonic mucosa except for the slight edema of the colon wall.