Clinical characteristics and risk factors of esophageal reflux hypersensitivity: A multicenter study

Table 2 Risk factor analysis

Variable	RH group (n = 92)	Control group (n = 104)	Univariate	Multivariate
			P value	OR	P value
Age, year (mean ± SD)	51.6 ± 13.1	41.8 ± 13.6	< 0.001
Youth/middle age/elderly	21/46/25	52/42/10	< 0.001	5.633	0.030
Gender (male/female)	37/55	57/47	0.041	1.492	0.296
BMI, kg/m2 (mean ± SD)	22.6 ± 2.8	23.2 ± 3.4	0.195
Higher education (yes/no)	27/65	62/42	< 0.001	0.647	0.335
Marriage (yes/no)	86/6	81/23	0.002	0.921	0.904
Comorbidity
Coronary disease (yes/no)	5/87	1/103	0.162
Hypertension (yes/no)	16/76	15/89	0.57
Diabetes (yes/no)	2/90	3/101	0.753
Hiatal hernia (yes/no)	12/80	1/103	0.001	13.103	0.020
IBS (yes/no)	25/67	15/89	0.027	1.539	0.384
Insomnia (yes/no)	70/22	53/51	< 0.001	2.572	0.053
Anxiety (yes/perhaps/no)	24/17/51	2/3/99	< 0.001	17.342	0.000
Depression (yes/perhaps/no)	2/22/68	0/3/101	< 0.001	0.598	0.613

Youth: Aged 18-40 years, middle age: Aged 40-60 years, elderly: Aged over 60 years. RH: Reflux hypersensitivity; OR: Odds ratio; BMI: Body mass index; IBS: Irritable bowel syndrome.