Effect of sex on the outcomes of peroral endoscopic myotomy for the treatment of achalasia

Table 4 Comparison of clinical characteristics between male and female subgroups (40 ≤ year < 60)

Variables	Pre-POEM			Post-POEM
	Group 2: Male, 40 ≤ year < 60 (n = 101)	Group 5: Female, 40 ≤ year < 60 (n = 136)	P value	Group 2: Male, 40 ≤ year < 60 (n = 101)	Group 5: Female, 40 ≤ year < 60 (n = 136)	P value
Eckardt scores
Dysphagia			0.270			0.862
0	0	0		43	62
1	15	14		51	67
2	19	19		3	4
3	67	103		4	3
Regurgitation			0.680			0.774
0	17	26		61	88
1	19	23		35	43
2	38	43		5	5
3	27	44		0	0
Chest pain			0.001			0.236
0	64	56		80	96
1	28	51		20	39
2	9	20		1	1
3	0	9		0	0
Weight loss			0.733			0.865
0	23	28		97	130
1	11	21		4	6
2	31	37		0	0
3	36	50		0	0
Total Eckardt scores (median IQR)	6.5 (5, 8)	7.1 (5, 9)	0.029	1 (0, 2)	1 (0, 2)	0.632
Chicago classification	n = 83	n = 108	0.430	n = 83	n = 108	0.430
1	13	11		13	11
2	63	90		63	90
3	7	7		7	7
HRM (median IQR)
LESP, mmHg (median IQR)	25.5 (20.6, 36.6)	33.2 (23.9, 43.5)	0.001	14.2 (10.9, 18.3)	16.6 (11.8, 21.5)	0.092
IRP, mmHg (median IQR)	21.6 (16.2, 27.1)	25.5 (20.2, 33.3)	0.003	9.4 (5.4, 15.3)	11.1 (8.6, 15.1)	0.266
Length of LES, cm (median IQR)	2.6 (2.0, 3.0)	2.5 (2.0, 3.0)	0.795	2.0 (1.7, 2.2)	1.8 (1.5, 2.9)	0.126
Iodipin column, mm (median IQR)
Height	81.3 (51.9, 106.6)	99.9 (68.7, 141.1)	0.061	47.8 (17.9, 84.9)	59.1 (42.2, 82.6)	0.645
Diameter	50.8 (38.2, 70.3)	42.3 (31.8, 55.7)	0.397	20.2 (14.1, 30.8)	24.8 (19.4, 39.5)	0.430

IQR: Interquartile range; POEM: Peroral endoscopic myotomy; HRM: High-resolution manometry; LESP: Lower esophageal sphincter pressure; IRP: Integrated relaxation pressure; LES: Lower esophageal sphincter.