Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis

Figure 7 Machine learning-based identification of key gut microbiota in hepatic fibrosis. A and B: The greatest differences in relative abundance between the hepatic fibrosis (HF) and non-HF groups according to the eXtreme gradient boosting (XGBoost) machine learning algorithm of top 10 phyla (A) and genera (B); C and D: The greatest differences in relative abundance between the mild HF and significant HF groups according to the XGBoost algorithm of top 10 phyla (C) and genera (D); E-G: The top 20 significant signatures of gut microbiota at the genus level according to the random forest algorithm. SHAP: Shapley additive explanations; HF: Hepatic fibrosis; mHF: Mild hepatic fibrosis; sHF: Significant hepatic fibrosis.