Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis

Figure 6 The relationship between key signaling pathways and hepatic fibrosis progression. A: The differential microbiota metabolic pathways between non-hepatic fibrosis (HF) and HF groups in Kyoto Encyclopedia of Genes and Genomes (KEGG) databases; B and C: The differential microbiota metabolic pathways between mild HF (mHF) and significant HF (sHF) groups in KEGG and MetaCyc databases, respectively; D: The subgroup analysis of mHF and sHF revealed 24 differential pathways in KEGG and MetaCyc databases. t-test was used to assess the significance of differences in microbial community functioning between different subgroups. HF: Hepatic fibrosis; mHF: Mild hepatic fibrosis; sHF: Significant hepatic fibrosis; TCA: Tricarboxylic acid; KEGG: Kyoto Encyclopedia of Genes and Genomes.