Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis

Figure 5 The relationship between gut microbiota, clinical indicators, and intestinal barrier function in different stages of hepatic fibrosis patients. A: The correlation analyses among gut microbiota, clinical indicators, and intestinal barrier function in hepatic fibrosis (HF) patients; B: The serum levels of γ-glutamyl transferase in different stages of HF patients; C-E: The serum levels of intestinal barrier function in different stages of HF patients. ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. ZO-1: Zonula occludens-1; AST: Aspartate aminotransferase; ALT: Alanine transaminase; ALB: Albumin; TBIL: Total bilirubin; IBIL: Indirect bilirubin; ALP: Alkaline phosphatase; WBC: White blood cell; BA: Basophil; PLT: Platelet; GGT: γ-glutamyl transferase; HF: Hepatic fibrosis; mHF: Mild hepatic fibrosis; sHF: Significant hepatic fibrosis.