Epstein-Barr virus infection is an independent risk factor for surgery in patients with moderate-to-severe ulcerative colitis

Table 2 Results of univariate logistic analysis

	Univariate logistic analysis		AUC
	P value	OR (95%CI)
Sex	0.486	1.283 (0.636-2.590)
Age (year)	0.002a	1.040 (1.014-1.067)	0.6651
Disease course (month)	0.623	1.001 (0.996-1.007)
Smoking history	0.219	0.266 (0.032-2.193)
History of surgery	0.785	0.882 (0.358-2.176)
Cardiovascular and cerebrovascular risk factors	0.178	1.71 7 (0.782-3.771)
History of malignant tumor	0.139	3.194 (0.686-14.878)
Fever	0.000a	5.814 (2.636-12.821)	0.6741
Complication	NC
Extraintestinal manifestations	0.415	1.577 (0.527-4.718)
Intestinal stenosis	0.128	2.211 (0.795-6.145)
UCEIS ≥ 5	0.652	1.174 (0.584-2.360)
Nancy index ≥ 3	NC
EBER positivity	0.000a	13.707 (4.700-39.977)	0.6791
CMV positivity	0.000a	44.545 (5.643-351.647)	0.6441
Fungal infection	0.012a	3.291 (1.306-8.293)	0.580
WBC count ( 109/L)	0.410	0.954 (0.851-1.068)
Hemoglobin (g/L)	0.000a	0.966 (0.949-0.983)	0.279
Platelet count ( 109/L)	0.124	0.998 (0.994-1.001)
C-reactive protein (mg/L)	0.000a	1.025 (1.014-1.037)	0.8141
ESR (mm/hour)	0.019a	1.017 (1.003-1.031)	0.6301
Albumin (g/L)	0.000a	0.855 (0.806-0.908)	0.212
Prealbumin (g/L)	0.003a	0.991 (0.986-0.997)	0.328
Treatment with ≥ 3 types of immunosuppressive drugs before admission	0.000a	6.942 (2.726-17.674)	0.6431
Antibiotic therapy with third-generation cephalosporins or more advanced antibiotics during admission	0.001a	5.512 (2.017-15.069)	0.6451

^aP < 0.05.

¹AUC > 0.6.

AUC: Area under the curve; UCEIS: Ulcerative colitis endoscopic index of severity; EBER: Epstein-Barr virus-encoded small RNA; CMV: Cytomegalovirus; WBC: White blood cell; ESR: Erythrocyte sedimentation rate; OR: Odds ratio; NC: Not calculated (comparison not feasible for computational reasons).