LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis

Figure 4 SLC7A11 is a direct target of lncRNA FTX/miR-625-5p signaling axis. A: The potential binding site between SLC7A11 and miR-625-5p predicted by Starbase; B: Pearson's correlation analysis was performed to determine the correlation between SLC7A11 and lncRNA FTX expression; C: SLC7A11 expression in colon cancer, rectal cancer, and paracancerous tissues; D: Relative expression of SLC7A11 in HT29R and HCT116R cells; E: Relative expression of SLC7A11 in HT29R-shFTX and HCT116R-shFTX cell lines; F: The targeting relationship between miR-625-5p and SLC7A11 was confirmed by dual-luciferase reporter assay in HT29R and HCT116R cells; G: Expression levels of SLC7A11 in HT29R-shFTX and HCT116R-shFTX cells with or without transfection of miR625-5p were determined by Western blotting. ^aP < 0.05 and ^bP < 0.01. NC: Negative control.