LncRNA FTX promotes colorectal cancer radioresistance through disturbing redox balance and inhibiting ferroptosis via miR-625-5p/SCL7A11 axis

Figure 2 Downregulation of lncRNA FTX increases ferroptosis sensitivity in colorectal cancer cells. A: Expression of ferroptosis-related proteins in HT29R, HCT116R cells after down-regulating lncRNA FTX; B: Glutathione content in HT29R and HCT116R cells after downregulating lncRNA FTX; C: Morphological changes in intracellular mitochondria in HT29R and HCT116R cells after knockdown of the lncRNA FTX were observed by electron microscopy; D: Cell viability was determined using CCK-8 assay after treatment by sh-FTX combined with RSL3 in HT29R and HCT116R cells. ^aP < 0.05 and ^bP < 0.01. NC: Negative control.