Predictive models and clinical manifestations of intrapulmonary vascular dilatation and hepatopulmonary syndrome in patients with cirrhosis: Prospective comparative study

Table 5 Predicted value information of different parameters and the combined model for intrapulmonary vascular dilatation and hepatopulmonary syndrome in patients with cirrhosis

Variables	Cut off value	Sensitivity	Specificity	Accuracy	PPV	NPV	Youden index
Predicting IPVD
Age, years	60	0.68	0.49	0.55	0.38	0.77	0.17
MELD score	9	0.78	0.55	0.63	0.45	0.85	0.33
P(A-a)O2, mmHg	24	0.52	0.72	0.65	0.49	0.73	0.23
S1P, pg/mL	36	0.58	0.69	0.66	0.46	0.78	0.27
Angiopoietin-2, pg/mL	2922	0.85	0.48	0.60	0.42	0.88	0.33
PDGF-BB, pg/mL	79	0.78	0.46	0.56	0.40	0.82	0.24
The combined model	0.27	0.87	0.59	0.69	0.52	0.90	0.47
Predicting HPS
Age, years	60	0.76	0.47	0.52	0.22	0.91	0.23
P(A-a)O2, mmHg,	18	0.96	0.64	0.71	0.41	0.99	0.60
HGB, g/L	115	0.72	0.55	0.58	0.25	0.91	0.27
Albumin, g/L	35	0.89	0.45	0.53	0.25	0.95	0.34
TBIL, μmol/L	29	0.81	0.61	0.64	0.30	0.94	0.42
S1P, pg/mL	36	0.61	0.65	0.64	0.26	0.89	0.26
Angiopoietin-2, pg/mL	4373	0.73	0.62	0.64	0.27	0.92	0.35
PDGF-BB, pg/mL	79	0.78	0.41	0.48	0.21	0.90	0.19
Combined model	0.14	0.94	0.74	0.78	0.47	0.98	0.68

HGB; Hemoglobin; HPS: Hepatopulmonary syndrome; IPVD: Intrapulmonary vascular dilatation; MELD: Model for End-Stage Liver Disease; NPV: Negative predictive value; P(A-a)O₂: Alveolar-arterial oxygen gradient; PDGF-BB: Platelet-derived growth factor BB; PPV: Positive predictive value; S1P: Sphingosine 1 phosphate; TBIL: Total bilirubin.