Multi-omics reveals the associations among the fecal metabolome, intestinal bacteria, and serum indicators in patients with hepatocellular carcinoma

Table 4 Correlations between differential metabolites and serum indicators

Serum indicator	HC vs HCC12			HC vs HCC34
	Metabolite	Coefficient	P value	Metabolite	Coefficient	P value
AST				25-Acetyl-6,7-didehydrofevicordin F 3-glucoside	6.92E-01	5.27E-03
				Coumatetralyl	6.42E-01	4.87E-02
ALB				25-Acetyl-6,7-didehydrofevicordin F 3-glucoside	-6.99E-01	3.68E-03
				Cholylglutamic acid	6.82E-01	8.41E-03
				Propamocarb	6.62E-01	2.07E-02
				3b-Hydroxy-6b-angeloyloxy-7(11)-eremophilen-12,8b-olide	6.55E-01	2.81E-02
				5-Ribosylparomamine	-6.50E-01	3.46E-02
GGT	4-Keto-2-undecylpyrroline	-7.01E-01	7.23E-03	Flurandrenolide	6.86E-01	6.99E-03
				Alanine amine	6.79E-01	9.67E-03
				Trans-Oct-2-enoyl-CoA	6.59E-01	2.34E-02
				1’-Hydroxyversicolorone	6.57E-01	2.62E-02
TBIL	(1S)-1-hydroxy-23,24-didehydro-25,26,27-trinorcalciol	-4.29E-01	6.47E-06	2-(Ethylamino)ethanol	6.83E-01	8.12E-03
	Dihydrojasmonic acid	-3.17E-01	1.15E-02	Vitamin A	-6.70E-01	1.49E-02
	Vamorolone	5.05E-01	1.33E-02	9-cis-Retinoic acid	-6.69E-01	1.52E-02
	3-NOR-3-OXOPANASINSAN-6-OL	-3.54E-01	2.85E-02	3,4-Dimethyl-5-pentyl-2-furanpropanoic acid	-6.57E-01	2.60E-02
	(6R,7S)-6,7-Epoxy-1,3-tetradecadiyne	-4.55E-01	3.34E-02
	1,8-Heptadecadiene-4,6-diyne-3,10-diol	-3.73E-01	3.39E-02
	9(S)-HOTrE	-2.56E-01	3.56E-02
AFP	(1S)-1-hydroxy-23,24-didehydro-25,26,27-trinorcalciol	-7.02E-01	6.95E-03
	Dihydrojasmonic acid	-6.97E-01	8.88E-03
	Vamorolone	6.95E-01	9.67E-03
	3-NOR-3-OXOPANASINSAN-6-OL	-6.85E-01	1.52E-02
	(6R,7S)-6,7-Epoxy-1,3-tetradecadiyne	-6.66E-01	3.51E-02
	1,8-Heptadecadiene-4,6-diyne-3,10-diol	-6.60E-01	4.35E-02

HC: Healthy control; HCC12: Comprising patients with stage I and II hepatocellular carcinoma; HCC34: Comprising patients with stage III and IV hepatocellular carcinoma; AST: Aspartate aminotransferase; ALB: Albumin; GGT: γ-glutamyl transferase; TBIL: Total bilirubin; AFP: Alpha-fetoprotein.