Study of the relationship between iron metabolism disorders and sepsis-associated liver injury: A prospective observational study

Table 3 Univariate logistic regression analysis of risk factors for sepsis-associated liver injury among patients with sepsis

Variables	OR	P value	95%CI
Age, year	1.00	0.729	0.97-1.02
BMI, kg/m2	1.05	0.292	0.96-1.15
PT, second	1.00	0.942	0.95-1.05
APTT, second	1.00	0.982	0.97-1.03
INR	0.92	0.565	0.68-1.24
PLT, 109/L	0.99	0.028a	0.99-0.99
ALB, g/L	1.12	0.002a	1.04-1.21
Lac, mmol/L	1.47	< 0.001a	1.19-1.80
IL-6, pg/mL	1.00	0.765	1.00-1.00
WBC, 109/L	1.01	0.678	0.97-1.04
NE, 109/L	1.00	0.910	0.97-1.03
SI, μmol/L	1.21	< 0.001a	1.12-1.32
TIBC, μmol/L	1.12	< 0.001a	1.06-1.17
sTfR, mg/L	1.17	0.140	0.95-1.45
SF, ng/mL	1.01	0.002a	1.01-1.01
TSAT, %	29.33	< 0.001a	5.30-162.35
Gender
Male	1.00		Reference
Female	0.66	0.266	0.32-1.37
Smoking history
No	1.00		Reference
Yes	1.47	0.280	0.73-2.95
Drinking history
No	1.00		Reference
Yes	3.92	< 0.001a	1.86-8.29
Hypertension
No	1.00		Reference
Yes	0.97	0.921	0.48-1.95
Diabetes
No	1.00		Reference
Yes	0.63	0.275	0.27-1.45
Abdominal infection
No	1.00		Reference
Yes	3.10	0.003a	1.49-6.44

^aP < 0.05.

OR: Odds ratio; CI: Confidence interval; BMI: Body mass index; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; PLT: Platelet; ALB: Albumin; IL-6: Interleukin-6; WBC: White blood cell; NE: Neutrophil; SI: Serum iron; TIBC: Total iron-binding capacity; sTfR: Soluble transferrin receptor; SF: Serum ferritin; TSAT: Transferrin saturation.