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©The Author(s) 2025.
World J Gastroenterol. Apr 14, 2025; 31(14): 104397
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.104397
Published online Apr 14, 2025. doi: 10.3748/wjg.v31.i14.104397
Table 2 Human leukocyte antigen-DQ genotypes associated with celiac disease
| HLA (genotype) | HLA (heterodimer) | CD (n = 746) | Controls (n = 627) | OR | P value | CI |
| HLA-DQA1 05 HLA-DQB1 02:01/HLA-DQA1 02:01 HLA-DQB1 02:02 | -DQ2.5/-DQ2.2 | 111 | 17 | 6.3 | 1.1 × 10-14 | 3.7-10.6 |
| HLA-DQA1 05 HLA-DQB1 02:01/HLA-DQA1 05 HLA-DQB1 02:01 | -DQ2.5/-DQ2.5 | 153 | 33 | 4.6 | 2 × 10-16 | 3.1-6.9 |
| HLA-DQA1 05 HLA-DQB1 02:01/HLA-DQA1 03:01 HLA-DQB1 03:02 | -DQ2.5/-DQ8 | 57 | 21 | 2.4 | 6.2 × 10-4 | 1.4-4.0 |
| HLA-DQA1 05 HLA-DQB1 03:01/HLA-DQA1 02:01 HLA-DQB1 02:02 | -DQ2.5 trans | 41 | 20 | 1.8 | 3.9 × 10-2 | 1.0-3.0 |
| HLA-DQA1 05 HLA-DQB1 02:01/HLA-DQA1 X HLA-DQB1X | -DQ2.5 cis | 271 | 165 | 1.6 | 7.2 × 10-5 | 1.3-2.0 |
| HLA-DQA1 02:01 HLA-DQB1 02:02/HLA-DQA1 X HLA-DQB1 X | -DQ2.2/X | 17 | 28 | 0.5 | 2.3 × 10-2 | 0.3-0.9 |
| HLA-DQA1 03:01 HLA-DQB1 03:02/HLA-DQA1 X HLA-DQB1 X | -DQ8/X | 15 | 38 | 0.3 | 1 × 10-4 | 0.2-0.6 |
- Citation: Schirru E, Rossino R, Jores RD, Corpino M, Muntoni S, Cucca F, Congia M. Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease. World J Gastroenterol 2025; 31(14): 104397
- URL: https://www.wjgnet.com/1007-9327/full/v31/i14/104397.htm
- DOI: https://dx.doi.org/10.3748/wjg.v31.i14.104397